Oncology /Immuno-oncology Platform
Non-Human Primates Platform
Inflammation/Autoimmune Diseases Model
Metabolic/Liver/Cardiovascular Diseases Model
HuPBMC reconstitution mouse model platform is created by engrafting human peripheral blood mononuclear cell (PBMC) into NOG mice to form a human-resembling immune system, which could be used for evaluate T cell modulating drugs.
Two different PBMC delivery approach: 1. Pre-mix PBMC and tumor cells then inject by subcutaneously; 2. Before tumor cell inoculation, injection of PBMC by intravenously or intraperitoneally.
Readouts: body weight, tumor growth inhibition, annotation of tumor infiltrating leukocytes (TIL) and tumor cells.