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HuPBMC Reconstitution Mouse Model

HuPBMC reconstitution mouse model platform is created by engrafting human peripheral blood mononuclear cell (PBMC) into NOG mice to form a human-resembling immune system, which could be used for evaluate T cell modulating drugs. 

Two different PBMC delivery approach: 1. Pre-mix PBMC and tumor cells then inject by subcutaneously; 2. Before tumor cell inoculation, injection of PBMC by intravenously or intraperitoneally. 

Readouts: body weight, tumor growth inhibition, annotation of tumor infiltrating leukocytes (TIL) and tumor cells.

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