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LPS-Induced Acute Lung Inflammation

In recent years, significant progress has been made in the research and development of anti-inflammatory and anti-infective drugs due to the improvement of small molecule drug screening technology and the development of bio-macromolecule drugs such as neutralizing antibodies. In the early stage of drug screening evaluation, it is necessary to select inexpensive and reliable inflammatory animal models and evaluation methods to conduct the preliminary pharmacodynamic evaluation program.

To establish a lung inflammation model, we chose the mouse lipopolysaccharide (LPS)-induced acute pneumonia model and validated its in vivo efficacy. The LPS-induced acute pneumonia model was established by the nasal inhalation method, and the pathological grading standard was established by HE staining of lung injury at different time points.

Case Study: LPS-induced acute lung inflammation in BALB/c mice

Aim: To examine the effect of dexamethasone on LPS-induced acute lung inflammation in BALB/c mice.

Animal:  BALB/c, female, 6-8 weeks, 18-20 g.

Reagent: LPS; Dexamethasone (Dex).


Effect of Dexamethasone on BALF Cells


Effect of Dexamethasone on Cytokines in BALF


Lung Pathology (H & E staining)


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