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Chemotherapy (Irinotecan)-induced mucositis model

A common complication of chemo or radio therapy in cancer patients is oral and gastrointestinal mucositis, an adverse reaction of painful inflammation and ulceration. It's primary caused when therapy attacks and kills the rapidly-dividing cells in mucous membrane and have risks of bacteremia. 

Mucositis can be so sever that it’s dose-limiting below the full therapeutic potential of the anti-cancer agent. 

When studies are directed towards mechanism investigation or related therapeutic verification, NHP model provides advantage of closer phylogenetic affinity and cross-reactivity to the human specific biological molecules that do not react with rodent counterpart.

Case Study:Chemotherapy-Induced Mucositis in Cynomolgus Monkey

Animal: Cynomolgus monkeys, female 

Material: Irinotecan (CPT-11)

Mucositis: Inflammation and Ulceration of The SI


Clinical Assessment of Mucositis


White Blood Cell (WBC) and Differential Counts


Similar to the decrease of WBC counts after CPT-11 challenge, Lymph#, Neu# and Eos# were also declined. ~12 days later, these cells went back to their baseline.

Villi shortening, crypt destruction, and impaired goblet cell mucin production was observed in the model.


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