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Transgenic Humanized Mice Models

PharmaLegacy has validated transgenic humanized mice models of CTLA4 and PD-1, a valuable platform for clients to study a range of specific human biological therapies in vivo, in mice, with a fully functional murine immune system featuring a humanized drug target. A murine target protein such as PD-1, for example, can be directly replaced with its human counterpart.

Examples:
Human CTLA4 Ab test in MC38 model

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Animal: CTLA4 Humanized Mouse Model, 4~5 weeks.

Tumor Cell: MC38 Mouse Colon Cancer, subcutaneous implantation.

Reagent: Anti-human-CTLA4


Case Study:
Human PD1 Ab test in MC38 model

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Animal: PD-1 Humanized Mouse Model, 4~5 weeks.

Tumor Cell: MC38 Mouse Colon Cancer, subcutaneous implantation.

Reagent: Anti-human-PD-1





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