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Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by chronic inflammation of the synovial membrane, which over time results in damage to the joints and leads to pain and disability. Rodent models with collagen II-induced arthritis (CIA) have been extensively used in academic research and the pharmaceutical industry for investigating the pathogenesis of RA and its treatments. An RA model in non-human primate (NHP) is particularly useful because of the close phylogenesis that provides the cross-reactivity to human for medical product development with most modern drug manufacturing technologies. Contrary to the successful RA modeling in rodents, NHP RA model has been reported to be extremely difficult because of the low and inconsistent disease incidence in both Rhesus macaques and Cynomolgus macaques, the most commonly used NHP for medical research. To solve this issue, scientists at PharmaLegacy developed a type II collagen-induced arthritis model in Cynomolgus monkeys, successfully establishing a reliable NHP arthritis model that can be used in rheumatology studies, as well as inflammation related anemia or pain studies, etc.


PharmaLegacy Models and Research Tools

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Case Study - Modeling Human Rheumatoid Arthritis in Cynomolgus Monkeys

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Collagen II Induced Arthritis: Histopathology Evaluation

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X-Ray Examination at the end of study

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