Services

Services

Metabolic diseases

PharmaLegacy has developed and validated several metabolic disease models, including diabetes, high-fat induced models and gout models to test pharmacological effects and mechanisms of candidate drugs. 


  Diabetes Mellitus 
   • Zuker fatty rats 
   •  Db/db mice 
   •  High fat diet-induced type II diabetes in rats and mice 
   •  STZ-induced type II diabetes in rats and mice 
   •  Diabetic nephropathy 
   •  Insulin 
  

  High-fat induced animal model 

   • High fat diet-induced hyperlipidemia in rats 
   • High cholesterol diet-induced hyperlipidemia in golden hamsters 
   • Fat emulsion by gavage in rats and mice 
   • High fat diet-induced obese in rats and mice 


  Gout model 

   • Gouty arthritis 
   • Uricase inhibitor-induced hyperuricemia in mice 
   • Uric acid hypoxanthine-induced hyperuricemia in mice


Endpoints


  Diabetes Mellitus

   - The levels of plasma insulin                                                        

   Glucose level in plasma                                                         
   - Total cholesterol (T-CHO)                                                        
   - Total triglyceride (TG)                                                               
   - Glucose tolerance test (GTT)                                                   
   - Insulin tolerance test (ITT)                                                        
   - The blood glycosylated hemoglobin (HbA1c) concentration         
   - Free fatty acid (FFA) level in plasma


  High-fat induced animal model
   - HbA1c concentrations in blood samples
   - Food intake
   - Body weight measurement
   - The levels of plasma insulin 
   - Glucose level in plasma
   - Total cholesterol (T-CHO) 
   - Total triglyceride (TG)
   - Free fatty acid (FFA) level in plasma


  Gout model
   - The diameter and surface temperature of knee joints
   - Pain measurement
   - The diameter of knee joints