How Proper DMPK Studies Can Lower Clinical Attrition Rates

October 27, 2022 /

Drug metabolism and pharmacokinetics (DMPK) are essential to understanding important characteristics of drug candidates, including absorption, distribution, metabolism, excretion, toxicity (ADMET), and pharmacokinetic (PK) properties. DMPK studies are conducted at the preclinical and clinical stages as well as post-approval. Preclinical DMPK studies involve both in vitro studies to evaluate drug candidate characteristics such as protein binding affinities and interactions with transporters and enzymes as well as in vivo analyses to assess toxicity and pharmacokinetics such as half-life, bioavailability, excretion, absorption, and distribution in preclinical animal models. Drug characteristics are further evaluated during clinical trials, including assessment of safety, dosage, side [...]

On the Role of Humanized Mouse Models in Immuno-oncology Research

October 14, 2022 /

If you’ve been keeping up with the latest advancements in cancer research, you might come across the usage of humanized mouse models as a promising tool in cancer management and treatment. This trend is driven by advances in the development of new rodent models which enabled scientists to further investigate and harness the power of immunotherapies in fighting tumors by replacing the mouse’s immune system with a functioning human one, hence the term “humanized”. But first, what is a humanized mouse model? A humanized mouse model is established by modifying specific genes that render it immunodeficient, lacking T, B, and [...]