DIABETES MELLITUS (DM) AND ITS COMPLICATIONS

Accelerating novel discoveries with a multitude of validated in vivo models.

According to the WHO, diabetes is the 9th leading cause of death in the United States, with more than 34 million people suffering from it, 20% of which aren’t even aware they have it. Unsurprisingly, the incidence of diabetes has skyrocketed in the past 20 years, more than doubling up as the American population has aged, become overweight and even obese.

We at PharmaLegacy are always hard at work, developing models to accelerate novel discoveries that might one day revolutionize how we approach metabolic diseases.

Choose the CRO with the most in vivo pharmacology experience. Choose PharmaLegacy.

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Diabetes Mellitus

MODELS / SERVICES

Case Study: The Db/db Mice Study

Endpoint Measurements

Body Weight

Fasting Glucose/Oral Glucose Tolerance OGTT

Plasma levels of TG and TC and Insulin

Case Study:

Diabetes Mellitus Model in NOD Mice

In this study, we observed that blood glucose in NOD mice begins to increase around 6 weeks of age and plateaus at 14 weeks of age.

·         When treated with Test article 1, diabetes incidence reached 25% at 9 weeks of age.

·         When treated with Test article 2 high dose 50mg/kg, diabetes incidence reached 12.5% at 9 weeks of age and 25.0% at 12 weeks of age.

·         When treated with Test article 2 middle dose 10mg/kg diabetes incidence reached 12.5% at 12 weeks of age and 25.0% at 13 weeks of age.

·         When treated with Test article 2 low dose 3mg/kg diabetes incidence reached 12.5% at 10 weeks of age.

Diabetes Model in NOD Mice

Body Weight

Blood Glucose Levels

The capability to succeed:

  • Staff with an average of 15+ years of pharmacology experience
  • 24/7 access to PharmaLegacy representatives
  • Real-time remote monitoring of studies
  • 45,000 square foot facility
  • Capacity to run 200+ concurrent animal studies

If uncompromised commitment is what you are looking for in a CRO, you’ve come to the right place. Get in touch with our experts at PharmaLegacy now.

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