HUMANIZED MOUSE MODELS
Versatility and reproducibility in oncology studies.
Humanized mouse models are the swiss-knives of preclinical models: they can be used to identify tumor stem cells, investigate tumor cell biology, identify and test potential drugs, and get a better insight on metastasis. Finding a CRO that provides you with the study designs and models you need for your immunological trials can be as daunting as the trials themselves: Hu-PBL-scid models ensuring flawless memory T cells, or Hu-SRC-scid models which will guarantee the multilineage development of hematopoietic stem cells, is challenging at best.
As the need for humanized models grows exponentially with all advances made in immunology, the lack of reliable, cost-effective platforms is proving to be an obstacle that many are finding hard to overcome. But not at Pharmalegacy.
Models / Services
The development of CD34+ humanized mouse model:
Availability of human tumor cell lines
Case Study: Immune Checkpoint Inhibitors-Evaluating mAb PD-1/PD-L1 in HCC-827 Model
Case Study: Immune Checkpoint Inhibitors-Evaluating mAb PD-1 in U87MG Model
Case Study: Combination Therapy-Evaluating mAbs PD-1 and EGFR in HCC-827 Model
Case Study: Bi-Specific Ab
Evaluating Bi-Specific Ab in HCC827 Model
Case Study: Oncolytic Virus
The Development of CD34+ Humanized Mouse Model
Human T Cell Proliferation in PB of HCC827 hCD34+ Humanized Model
PD-1/PD-L1 Combination Therapy in HCC827 hCD34+ Humanized Model
PD-L1&VEGF Combination Therapy in U87MG hCD34+ Humanized Model
PD-1&HER-2 Combination Therapy in HCC1954 hCD34+ Humanized Model
PD-1/PD-L1-VEGF Bi-Specific Abs Therapy in hCD34+ Humanized Model
Oncolytic Virotherapy in hCD34+ Humanized Model
Cell Lines Validated in hCD34+ Humanized Model
Two different PBMC delivery approach:
Committed to quality:
- Capacity to house over 30,000 rodents and large animals
- Scientific staff with an average of over 15 years of pharmacology experience.
- FDA Part 11 compliant
- 24/7 access to PharmaLegacy representatives.
Never settle for less in your preclinical oncology trial. Contact us at PharmaLegacy let’s talk about your expectations, and how we can exceed them together.
Top Pharmaceutical Companies Trust PharmaLegacy for their Oncology Trials
“The study they delivered on a very reasonable budget was top notch […] The model was executed flawlessly.”
See why a top-20 pharmaceutical company trusts PharmaLegacy for their preclinical immuno-oncology trials.