OCULAR INFLAMMATION MODELS

Critical ocular inflammation studies call for the best in vivo models.

Ocular inflammation has multiple etiologies, ranging from contact lens wear, trauma and allergens to dietary and lifestyle changes. Even though the triggers of ocular inflammation are numerous, the symptoms produced are all similar, given that they all ultimately induce the same immunological cascade. This partially explains why most treatments of different types of ocular inflammation are almost identical.

The gap in ocular inflammation studies is therefore the lack of targeted treatments for each underlying etiology. This is where your studies and our expertise in pharmacology comes into play. Get in touch with one of our experts now and let’s discuss things further.

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Ocular Inflammation

MODELS / SERVICES

Case: Compounds on Bovine IRBP R16-Induced EAU in Lewis Rats

Experimental Procedures

·         Animal species and strain: Lewis rats

·         History of treatment: naive

·         Food: free access to food

·         Water: free access to water

·         Reagents: IRBP R16 solution/ Modified Complete Freund’s Adjuvant (CFA)

Experimental Results

Effect of FTY-720 on Bovine IRBP R16-Induced EAU in Lewis Rats


Histopathology Photo

Case: Compounds on Experiment Allergic Conjunctivitis in BALB/C mice.

Experimental Procedures

·       Animal species and strain: BALB/c mice

·       History of treatment: Naive

·       Sex, age and weight: Female, 6 – 8 weeks.

·       Food: Free access to food

·       Water: Free access to water

·       Reagent: Ovalbumin (OVA)/ Inject Alum hydroxide solution

Total Score of Hyperemia and Edema

Count of Eye Scratching

Histopathological Eosinophils Detection


Enforcing quality:

  • Rigorous adherence to international GLP and QA best practices
  • 600+ validated animal models of disease spanning 40+ diseases
  • FDA Part 11 compliant
  • PK/PD, molecular pharmacology and preliminary toxicology adjacency studies

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