PNEUMONITIS / ACUTE LUNG INFLAMMATION MODELS

Validated in vivo models for critical pneumonitis and acute lung inflammation studies.

Pneumonitis is one of the leading causes of Acute Lung Injury (ALI). First described in 1967, ALI, which ultimately develops into Acute Respiratory Distress Syndrome (ARDS), is a leading cause of acute respiratory failure in critically ill patients. The mechanisms behind the pathophysiologic exacerbations of ALI into ARDS remain till today poorly understood, justifying the need for more advanced preclinical models that better replicate the clinical manifestations of ALI.

Every year, 74,500 out of 190,000 patients suffering from ALI will succumb to it. This needs to change. At PharmaLegacy, our preclinical models are designed by experts in pharmacology that can ensure pathophysiologic accuracy, and more importantly, translatability of your pipelines.

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Pneumonitis / Acute Lung Inflammation

MODELS / SERVICES

Case Study: LPS-induced acute lung inflammation in BALB/c mice

Aim: To examine the effect of dexamethasone on LPS-induced acute lung inflammation in BALB/c mice.

Animal:  BALB/c, female, 6-8 weeks, 18-20 g.

Reagent: LPS; Dexamethasone (Dex).

Effect of Dexamethasone on BALF Cells

Effect of Dexamethasone on Cytokines in BALF

Lung Pathology (H & E staining)

Pioneering Healthcare Solutions:

  • 150,000 square feet of facility space
  • Research data electronically managed by BioBook (IDBS, UK)
  • Real-time remote monitoring of studies
  • Electronically managed, traceable research data

Have high expectations for your pipeline? Get in touch, and let’s discuss how we can exceed them.

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