Quick and cost-effective screening for your drug discovery.

In vitro ADME (Absorption, Distribution, Metabolism, and Excretion) assays are premier tools used to screen compounds at the early discovery stage. ADME studies can quickly and cost effectively screen out compounds with various liabilities. From liver microsome/hepatocyte assays that can be used to assess metabolic stabilities before in vivo screening to reaction phenotyping that can be used to understand metabolizing isozymes and assess polymorphism liabilities and MetID tools that can be used to locate soft spots on chemotypes to help chemistry teams quickly improve your compound’s in vivo half-life, PharmaLegacy has you covered.

At PharmaLegacy, we provide quality and efficient ADME screening assays for your drug discovery effort with a fast turnaround time.

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In Vitro ADME Assays

ADME Services


  • Thermodynamic solubility
  • Kinetic solubility


  • Stability in PBS
  • Stability in Simulated Gastric Fluid (SGF)
  • Stability in Fasted State Simulated Intestinal Fluid (FaSSIF)
  • Stability in Fed State Simulated Intestinal Fluid (FeSSIF)

Metabolic Stability

  • Microsomal stability
  • Hepatocyte stability
  • Blood/Plasma stability


  • Caco-2

Partition / Binding

  • Plasma protein binding (PPB)
  • Red Blood Cell (RBC) to Plasma Partitioning

Drug-Drug Interaction (DDI)

  • CYP inhibition
  • CYP induction
  • CYP reaction phenotyping
  • Instrumentation: High Resolution Mass Spectrometry (Waters Synapt G2-Si)
  • Metabolite ID with liver microsome/hepatocyte incubation
  • Metabolite ID in Blood/Tissue
  • Soft spot check/semi-quantitation

Enforcing quality:

  • 1,000+ validated animal models of disease spanning 40+ diseases
  • FDA Part 11 compliant
  • Rigorous adherence to international GLP and QA best practices
  • PK/PD, molecular pharmacology and preliminary toxicology adjacency studies

Seeking uncompromising quality with deep skills and knowledge? Contact PharmaLegacy.

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