In 2008, the mummy of king Mernepath, an egyptian pharaoh who ruled over Egypt some 3,200 years ago was put under investigation along with other mummies to confirm their cause of death, which was hypothesized to be atherosclerosis. Surprisingly, all mummies showed fatty buildups in their arteries. Atherosclerosis, an inflammatory disease affecting 101 in 1,500, was always thought to be caused by modern lifestyles: smoking, diabetes, a sedentary lifestyle, etc., none of which were prevalent 3,200 years ago.
If there is one thing the scientific method has taught us at PharmaLegacy, it’s skepticism. Some inflammatory and immune diseases have been described in the literature for ages, long before NHP models were developed. Yet sometimes, mummies that were left untouched for thousands of years prove to us that we should always remain skeptical: nothing is written in stone in science. Whether you are trying to bolster established literature, or challenge what was once thought to be written in stone, PharmaLegacy has your back!
MODELS / SERVICES
Case Study：TTx-Induced DTH in Cynomolgus Monkey
Case Study：Chemotherapy-Induced Mucositis in Cynomolgus Monkey
DSS-Induced Colitis in Cynomolgus Monkey
Collagen II-Induced Arthritis (CIA) in Cynomolgus Monkey
I.V. LPS-Induced Cytokines Production in Cynomolgus Monkey
Case Study：LPS-Induced Systemic Inflammation Model
Case Study: Anti-inflammatory activity of the bradykinin B1R antagonist in a model of LPS-induced lung inflammation in the cynomolgus monkey
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No animal study can predict with complete certainty how a therapy will perform in human subjects, but it is PharmaLegacy’s job to ensure that you come as close to certainty as possible. Download our brochure on non-human primate (NHP) models and see how PharmaLegacy ensures that your studies utilize the most physiologically relevant models.