IN VITRO/ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) models
Prime ADME studies.
In vitro ADME models, or in vitro pharmacokinetic models can be used in a plethora of studies, ranging from permeability studies, plasma binding protein analysis, and red blood cell/plasma partition ratio to P450 enzyme studies and liver metabolite stability. ADME models can also be used to better explore antibacterial pharmacodynamics, and when used in conjunction with both animal models and human studies, can provide essential data on a drug’s pharmacodynamic properties.
Whether you are tackling descriptive studies on the effect of a simulated human dose, or performing analytic studies to find the optimal association of a particular pharmacodynamic factor with a drug’s action, you’ve come to the right place. ADME is our middle name at PharmaLegacy, and we’re here for you from the PK studies of your compound, until it makes it to the clinical setting.
MODELS / SERVICES
- 600+ validated animal models of disease spanning 40+ diseases
- FDA Part 11 compliant
- Rigorous adherence to international GLP and QA best practices
- PK/PD, molecular pharmacology and preliminary toxicology adjacency studies