Leading the waltz between therapeutic levels and toxic side effects.


It takes roughly 336.43 ng of type A botulinum toxin to kill a full grown man. In contrast, that same full grown man needs to drink more than 3-4L of water per hour to die of water intoxication. At PharmaLegacy, we believe that this is where the beauty of toxicology lies: in the narrowness of therapeutic indexes. Take digoxin for example: one of the oldest medications used for the treatment of heart diseases, its therapeutic levels lie between 0.8 and 2.0 ng/mL. Increasing this level by a mere 4 ng/mL (totalling more than 2.4 ng/mL) will lead to digoxin toxicity, begetting blurred vision, cardiac disturbances, restlessness, headache, confusion and more side effects.

Years of experience at PharmaLegacy has taught our experts how to waltz around Therapeutic Indexes. When just a few nanograms are all it takes to save a patient’s life, or end it, you can count on PharmaLegacy to identify those fine lines.

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Seeking precision tailored solutions for your pipelines? PharmaLegacy has all the answers.